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Part III: Guidelines for selected antimicrobial use

3.9 Ceftaroline

  1. Ceftaroline is a newer cephalosporin with in vitro activity against MRSA.
  2. Ceftaroline is inactive against ESBL-producing or AmpC-overexpressing Enterobacteriaceae and has limited activity against non-fermenting Gram-negative bacilli such as Pseudomonas aeruginosa and Acinetobacter baumannii (168).
  3. Dosing
    • Community acquired pneumonia: 600 mg I.V. q12h
    • Skin and soft tissue infection: 600 mg I.V. q12h
  4. Consult clinical microbiologist or infectious disease physician for the use of ceftaroline.