Part III: Guidelines for Selected Antimicrobial Use

3.9 Ceftolozane-tazobactam

Ceftolozane is a cephalosporin with an enhanced affinity for the penicillin-binding proteins of Pseudomonas aeruginosa. [254]
Documented activity against many ESBL-producing Enterobacterales, and some multidrug resistant P. aeruginosa. [254]
It is not generally active against carbapenemase-producing Enterobacterales. [254,260]
Ceftolozane-tazobactam can be used to treat complicated intra-abdominal infections (cIAI) (in combination with metronidazole), complicated urinary tract infections (cUTI), hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
Dosing [135]

Adults with creatinine clearance (CrCl) >50 mL/min

Ceftolozane-tazobactam 1.5–3 g every 8 hours by intravenous infusion over 1 hour

Dose adjustment is needed in persons with CrCl ≤50 mL/min.

Please consult a clinical microbiologist or infectious disease physician for the use of ceftolozane-tazobactam.