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Part III: Guidelines for Selected Antimicrobial Use



3.9 Ceftolozane-tazobactam



  1. Ceftolozane is a cephalosporin with an enhanced affinity for the penicillin-binding proteins of Pseudomonas aeruginosa. [254]

  2. Documented activity against many ESBL-producing Enterobacterales, and some multidrug resistant Paeruginosa. [254]

  3. It is not generally active against carbapenemase-producing Enterobacterales. [254,260]

  4. Ceftolozane-tazobactam can be used to treat complicated intra-abdominal infections (cIAI) (in combination with metronidazole), complicated urinary tract infections (cUTI), hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).

  5. Dosing [135]

Adults with creatinine clearance (CrCl) >50 mL/min

Ceftolozane-tazobactam 1.5–3 g every 8 hours by intravenous infusion over 1 hour

Dose adjustment is needed in persons with CrCl ≤50 mL/min.

  1. Please consult a clinical microbiologist or infectious disease physician for the use of ceftolozane-tazobactam.