Preface

Antimicrobial resistance (AMR) is a formidable challenge that threatens global health security. Defined as the ability of microorganisms to adapt and withstand the effects of antimicrobial agents, AMR poses a grave threat to modern medicine. The impact of AMR is starkly evident, with a rising number of lives lost to untreatable infections. In Hong Kong alone, projections indicate a staggering 18,433 deaths related to AMR, costing US$4,300 million from 2020 to 2030.

For over a quarter of a century, IMPACT has been at the forefront of efforts to combat AMR by promoting the judicious use of antimicrobial agents. As we unveil the sixth edition of IMPACT, our commitment to providing evidence-based guidance tailored to the unique epidemiological landscape of Hong Kong remains unwavering. This edition involved and is supported by the Hospital Authority, Centre for Health Protection, University of Hong Kong, Chinese University of Hong Kong, Hong Kong Medical Association, and Hong Kong Private Hospital Association.

I extend my heartfelt appreciation to the dedicated experts whose invaluable insights have shaped this publication. Special thanks are due to the Centre for Health Protection for their unwavering support in facilitating the production and dissemination of IMPACT. It is my sincere hope that this guideline will serve as a useful reference tool for healthcare professionals in optimizing antibiotic use and safeguarding the efficacy of these crucial therapeutics.

Dr. HO Pak Leung, J.P.
Chairman, IMPACT Editorial Board
May 2025