Part III: Guidelines for Selected Antimicrobial Use

3.10 Cefiderocol

1. Cefiderocol consists of a cephalosporin and a siderophore which binds iron, allowing it to enter bacteria through iron transporters. After entry, the cephalosporin detaches from iron and binds primarily to PBP3 and inhibits bacterial cell wall synthesis. [256,261]

2. It may be active against some Gram-negative bacteria. [262,263] It has no activity against Gram-positive and anaerobic bacteria. [264]

3. Cefiderocol can be used to treat urinary tract infections, hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. [262]

4. Dosing

5. Please consult a clinical microbiologist or infectious disease physician for the use of cefiderocol.