Home > Chapters
Part III: Guidelines for selected antimicrobial use
3.8 Once daily aminoglycosides
- Once daily aminoglycoside is an effective, well-established method to achieve therapeutic efficacy while limiting the risk of toxicity and simplifying the processes of dosing and monitoring (162–163).
- The addition of an aminoglycoside to β-lactams for sepsis should be discouraged. Combination treatment carries a significant risk of nephrotoxicity without survival benefits (164–165).
- With the exception of Enterococcus endocarditis (166), aminoglycosides should not be given for more than one or two doses.
- As concentration-dependent antibiotics, dosing of gentamicin and amikacin should keep the maximum serum concentration (Cmax) to minimum inhibitory concentration (MIC) ratio to 8–10 for optimal treatment outcome (167).