Part III: Guidelines for Selected Antimicrobial Use

3.13 Once Daily Aminoglycosides

1. Once daily aminoglycoside is an effective and established method to achieve therapeutic efficacy while limiting the risk of toxicity and simplifying the processes of dosing and monitoring. [273]

2. Results from meta-analyses suggested that the β-lactam-aminoglycoside combination did not provide an advantage over β-lactams alone, while the former was associated with nephrotoxicity. [274,275]

3. With a few exceptions, in general, aminoglycosides should not be given for more than two days. [276,277]

4. The most prevalent side effects of aminoglycosides are nephrotoxicity and ototoxicity. Ototoxicity can influence both vestibular and auditory functions. [278]

5. Aminoglycosides were associated with neuromuscular blockade and may worsen myasthenia gravis. [279,280]

6. If there is any uncertainty, please consult a clinical microbiologist or infectious disease physician for the use of aminoglycosides.