Tables & Figures
Tables
Table 8.2 Cross-reacting side chains between ß-lactam antibiotics
| Amoxicillin | Ampicillin | Cefaclor | Cefadroxil | Cefepime | Cefoperazone | Cefotaxime | Cefoxitin | Cefpodoxime | Ceftazidime | Ceftibuten | Ceftriaxone | Cefuroxime | Cephalexin | Cephaloridine | Cephalothin | Cephradine | Penicillin G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amoxicillin | 6 | 6/7 | 6/7 | 6/7 | 6/7 | |||||||||||||
| Ampicillin | 6 | 6/7 | 6/7 | 6/7 | 6/7 | |||||||||||||
| Cefaclor | 6/7 | 6/7 | 7 | 7 | 7 | |||||||||||||
| Cefadroxil | 6/7 | 6/7 | 7 | 3,7 | 3,7 | |||||||||||||
| Cefepime | 7 | 7 | 7 | |||||||||||||||
| Cefoperazone | ||||||||||||||||||
| Cefotaxime | 7 | 7 | 7 | 3 | ||||||||||||||
| Cefoxitin | 3 | 7 | 7 | 6/7 | ||||||||||||||
| Cefpodoxime | 7 | 7 | 7 | |||||||||||||||
| Ceftazidime | ||||||||||||||||||
| Ceftibuten | ||||||||||||||||||
| Ceftriaxone | 7 | 7 | 7 | |||||||||||||||
| Cefuroxime | 3 | |||||||||||||||||
| Cephalexin | 6/7 | 6/7 | 7 | 3,7 | 3,7 | |||||||||||||
| Cephaloridine | 7 | 7 | 6/7 | |||||||||||||||
| Cephalothin | 3 | 7 | 7 | 6/7 | ||||||||||||||
| Cephradine | 6/7 | 6/7 | 7 | 3,7 | 3,7 | |||||||||||||
| Penicillin G | 6/7 | 6/7 | 6/7 |
Numbers denote position of side chains: 3, similarity at the cephalosporin 3—position side chain; 7, similarity at the cephalosporin 7—position side chain; 6/7, similarity at the penicillin 6—position side chain and the cephalosporin 7—position side chain.
Each number in the matrix indicates side-chain similarity between two drugs. Cross-allergenicity is expected between each similar pair. For example, a patient allergic to amoxicillin would very likely manifest an allergic reaction to ampicillin, cefadroxil, cefaclor, cephalexin and cephradine. However, the patient would not be expected to exhibit an allergic response to cefepime, cefoperazone, cefotaxime, etc., unless he/she was also allergic to another cephalosporin or penicillin with a similar side chain to the reference drug.
Reference: (514)
