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Table 7.4 Dosage of antimicrobial agents for central nervous system infections

Antibiotics1 Recommended doses Cost (HK$/day)
I.V. cefotaxime 2 g q4h 48
I.V. ceftriaxone 2 g q12h 19
I.V. cefepime 2 g q8h 612
I.V. meropenem 2 g q8h 197
I.V. ampicillin 2g q4h 53
I.V. penicillin G 3–4 million unit q4h 118–157
I.V. metronidazole 500 mg q6h 18
I.V. vancomycin 1 g q12h 54
P.O. rifampicin2 600 mg once daily 1

 

Note:

  1. 1Dosage for a typical body weight ≥70 kg and normal renal function.
  2. 2Rifampicin should only be used in combination with another antibiotic for meningitis by certain bacteria (e.g. multi-resistant Streptococcus pneumoniae or MRSA) with documented sensitivity in susceptibility testing.