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Table 6.1 Suggested initial dose and time to re-dose for selected antimicrobial agents used for surgical prophylaxis

Antimicrobial agent Standard I.V. dose 1 Recommended re-dosing interval (hour)
Cefazolin 1–2 g 2–5
Cefuroxime 1.5 g 3–4
Clindamycin 600–900 mg 3–6
Amoxicillin-clavulanate 1.2 g 2–3
Ampicillin-sulbactam 1.5 g 2–3
Metronidazole 500 mg 6–8
Vancomycin 1 g infuse over 60 min 6–12

1In patient with normal renal function and not morbidly obese.