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Table 6.1 Suggested initial dose and time to re-dose for selected antimicrobial agents used for surgical prophylaxis
| Antimicrobial agent | Standard I.V. dose 1 | Recommended re-dosing interval (hour) |
|---|---|---|
| Cefazolin | 1–2 g | 2–5 |
| Cefuroxime | 1.5 g | 3–4 |
| Clindamycin | 600–900 mg | 3–6 |
| Amoxicillin-clavulanate | 1.2 g | 2–3 |
| Ampicillin-sulbactam | 1.5 g | 2–3 |
| Metronidazole | 500 mg | 6–8 |
| Vancomycin | 1 g infuse over 60 min | 6–12 |
1In patient with normal renal function and not morbidly obese.
