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Table 4.4 Comparative activities of commonly used ß-lactams against S. pneumoniae with different levels of penicillin susceptibility
| Agent | Penicillin MIC | |||
|---|---|---|---|---|
| ≤0.06 μg/mL | 0.12−1 μg/mL | 2 μg/mL | ≥4 μg/mL | |
| Penicillin V | +++ | + | - | - |
| Penicillin G | +++ | +++ | ++ | ± |
| Ampicillin P.O. | +++ | ++ | ± | - |
| Ampicillin I.V. | +++ | +++ | ++ | ± |
| Amoxicillin P.O. | +++ | ++ | + | - |
| Piperacillin | +++ | ++ | + | - |
| Ticarcillin | ++ | + | - | - |
| Cefotaxime | +++ | +++ | ++ | ± |
| Ceftriaxone | +++ | +++ | ++ | ± |
| Cefepime | +++ | ++ | + | ± |
| Cefuroxime I.V. | +++ | ++ | + | - |
| Cefuroxime P.O. | +++ | ++ | ± | - |
| Cefpodoxime | +++ | ++ | - | - |
| Ceftazidime | +++ | + | - | - |
| Cefaclor | +++ | - | - | - |
| Cefixime/ceftibuten | +++ | - | - | - |
| Imipenem/meropenem | +++ | +++ | + | - |
Penicillin MIC interpretation criteria (μg/mL) for I.V. penicillin G: meningitis ≤0.06 sensitive, ≥0.12 resistant; nonmeningitis ≤2 sensitive, 4 intermediate and ≥8 resistant.
Approximate in vitro activity was indicated by: - inactive, + weak activity, ++ good activity, +++ excellent activity, ± variable or dose-dependent
