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Table 4.3 Interpretation of penicillin susceptibility for S. pneumoniae

Syndrome, route of administration and agent Penicillin or amoxicillin MIC (μg/mL)
Susceptible Intermediate Resistant
Meningitis, Parenteral penicillin ≤ 0.06 - ≥ 0.12
Non-meningitis, Parenteral penicillin ≤ 2 4 ≥ 8
Non-meningitis, Oral (high dose) amoxicillin or amoxicillin-clavulanic acid ≤ 2 4 ≥ 8
Oral penicillin V ≤ 0.06 0.12–1 ≥ 0.12