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Table 3.2 Mechanisms of antifungal action
| Primary mode of action | Target | |
|---|---|---|
| Azoles (fluconazole, itraconazole, voriconazole) |
Inhibit ergosterol biosynthesis | Fungal cytochrome P-450 dependent 14 α-sterol demethylase |
| Echinocandins (caspofungin, anidulafungin, micafungin) |
Inhibit fungal cell wall glucan synthesis | Fungal β-1, 3-glucan synthase |
| Amphotericin B | Bind to and make fungal cell membrane ‘leaky’ | Fungal cell membrane |
