|
Primary mode of action |
Target |
Azoles
(fluconazole, itraconazole, voriconazole) |
Inhibit ergosterol biosynthesis |
Fungal cytochrome P-450 dependent 14 α-sterol demethylase |
Echinocandins
(caspofungin, anidulafungin, micafungin) |
Inhibit fungal cell wall glucan synthesis |
Fungal β-1, 3-glucan synthase |
| Amphotericin B |
Bind to and make fungal cell membrane ‘leaky’ |
Fungal cell membrane |
