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Table 1.8 Different classes of carbapenemase

  Class A Metallo-ß-lactamase OXA carbapenemase
Molecular class Class A Class B Class D
Functional class 2f 3 2d
Gene location Usually transposon Usually plasmid Usually plasmid
Examples KPC1
GES
SME
IMI/NMC1		 IMP1
VIM1
NDM1		 OXA-23, 24, 51, 58
(types in Acinetobacter spp.)2
OXA-48, 181, 232
(types in Enterobacteriaceae)1
Found in Enterobacteriaceae Non-fermenters and Enterobacteriaceae Non-fermenters and Enterobacteriaceae
Inhibited by Clavulanate and tazobactam EDTA No effective inhibitor
Active site Serine Zinc ion Serine
Carbapenem Hydrolysed Hydrolysed Hydrolysed
Aztreonam Hydrolysed Not hydrolysed Not hydrolysed
Early ß-lactam Hydrolysed Hydrolysed Hydrolysed
Extended spectrum cephalosporin Hydrolysed (except SME) Hydrolysed Hydrolysed poorly

 

Note:

  1. 1Seen in HK
  2. 2Common in HK