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Table 1.7 Characteristics of ESBL and AmpC ß-lactamases
| ESBL | AmpC ß-lactamase | |
|---|---|---|
| Bush-Jacoby-Medeiro functional class | 2be | 1 |
| Ambler molecular classification | A | C |
| Plasmid mediated | Almost always (responsible for the spread) | Most are chromosomal plasmid increasingly reported |
| ß-lactamase inhibitor | Inhibited | Not inhibited |
Cephamycins
|
Not hydrolysed | Hydrolysed |
Oxyimino-ß-lactams
|
Hydrolysed | Hydrolysed |
| Cefepime | Variable | Not hydrolysed |
| Carbapenem | Not hydrolysed | Not hydrolysed |
| Examples | TEM, SHV and CTX-M | Enterobacter, Citrobacter and Serratia possess inducible AmpC ß-lactamase encoded in their chromosomes |
