Part III: Guidelines for Selected Antimicrobial Use
3.6 Fosfomycin trometamol
A low-molecular-weight phosphoric acid derivative antibiotic which inhibits bacterial cell wall synthesis. [231]
In vitro activity against a variety of Gram-positive and Gram-negative bacteria, including Escherichia coli and Staphylococcus aureus. [232]
Acinetobacter species, Burkholderia cepacia, Bacteroides species, Morganella morganii, Pseudomonas species, Stenotrophomonas maltophilia, Staphylococcus capitis, and Staphylococcus saprophyticus are intrinsically resistant to fosfomycin. [232,233]
Oral fosfomycin trometamol (3 g in a single dose) can be a treatment choice for acute uncomplicated urinary tract infection in premenopausal, non-pregnant women with no known urological abnormalities or co-morbidities, although it appears to have inferior efficacy compared to other standard therapy. [234–237]
Adverse reactions (non-exhaustive)
- For treatment of infections other than uncomplicated cystitis, please consult a clinical microbiologist or infectious disease physician regarding the use of fosfomycin.