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Part III: Guidelines for selected antimicrobial use
- Daptomycin belongs to the antibiotic group lipopeptide. It possesses in vitro activities against a range of Gram-positive bacteria such as methicillin-sensitive Staphylococcus aureus (MSSA), MRSA, VRE, Staphylococcus epidermidis (including methicillin resistant), Streptococcus pyogenes and other streptococci.
- Bacteraemia associated with intravascular catheter
- S. aureus bacteraemia, including right-sided infective endocarditis
- Complicated skin and soft tissue infection
- Not indicated for pneumonia because of drug inactivation by pulmonary surfactant.
- Dosage: 4–6 mg/kg I.V. once daily.
- Side effects
- Myopathy and rhabdomyolysis especially in patients taking statins.
- Eosinophilic pneumonia related to the use of daptomycin has been reported (152).
- Please consult clinical microbiologist or infectious disease physician for the use of daptomycin.