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Part III: Guidelines for selected antimicrobial use

3.3 Daptomycin

  1. Daptomycin belongs to the antibiotic group lipopeptide. It possesses in vitro activities against a range of Gram-positive bacteria such as methicillin-sensitive Staphylococcus aureus (MSSA), MRSA, VRE, Staphylococcus epidermidis (including methicillin resistant), Streptococcus pyogenes and other streptococci.
  2. Indications
    • Bacteraemia associated with intravascular catheter
    • S. aureus bacteraemia, including right-sided infective endocarditis
    • Complicated skin and soft tissue infection
  3. Not indicated for pneumonia because of drug inactivation by pulmonary surfactant.
  4. Dosage: 4–6 mg/kg I.V. once daily.
  5. Side effects
    • Myopathy and rhabdomyolysis especially in patients taking statins.
    • Eosinophilic pneumonia related to the use of daptomycin has been reported (152).
  6. Please consult clinical microbiologist or infectious disease physician for the use of daptomycin.