Calculator

Time above MIC calculator for beta-lactams

Dose	mg
Serum half-life, T1/2	Hours
Volume of distribution, Vd	L/kg
Body weight	kg
Dosing interval	Hours
Minimal inhibitory concentration, MIC	mg/L
Reset
Time above MIC (T > MIC):	%

Formula

%T > MIC = In ( dose / (Vd x BW x MIC) ) x (T1/2) / ln2 x 100 / DI

Where
ln = natural logorithm;
Vd = volume of distribution (L/kg);
BW = Body weight (kg);
T 1/2 = Serum half-life (hours); and
DI = dosing interval (hours)

Footnote
Calculation according to the one-component first-order elimination model as derived by Turnidge JD 1998