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# Calculator

## Time above MIC calculator for beta-lactams

Formula

%T > MIC = In ( ) x x

Where

ln = natural logorithm;

Vd = volume of distribution (L/kg);

BW = Body weight (kg);

T 1/2 = Serum half-life (hours); and

DI = dosing interval (hours)

Footnote

Calculation according to the one-component first-order elimination model as derived by Turnidge JD 1998