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Time above MIC calculator for beta-lactams

Dose mg
Serum half-life, T1/2 Hours
Volume of distribution, Vd L/kg
Body weight kg
Dosing interval Hours
Minimal inhibitory concentration, MIC mg/L
Time above MIC (T > MIC): %

 

Formula

%T > MIC = In ( dose / (Vd x BW x MIC) ) x (T1/2) / ln2 x 100 / DI

Where
ln = natural logorithm;
Vd = volume of distribution (L/kg);
BW = Body weight (kg);
T 1/2 = Serum half-life (hours); and
DI = dosing interval (hours)

Footnote
Calculation according to the one-component first-order elimination model as derived by Turnidge JD 1998